HPE ProLiant ML350 Gen11 4510 12-core 64GB-R MR408i-o 8SFF 2x960GB SSD 2x1000W RPS EU Server

Lifecycle

• Obsolete Date 04-03-2026

Specifications

• Accelerators Optional: Supports NVIDIA L40/A16/L4/RTX 4000 Ada Graphics Accelerator for HPE, pending configuration
• Form factor 4U Tower
• Processor name Intel® Xeon® Silver 4510 (12 core, 2.40 GHz, 30 MB L3, 150W)
• Included drives 2x HPE 960GB SATA 6G Mixed Use SFF BC Multi Vendor SSD
• Included memory 64 GB (2×32 GB, 5600 MT/s)
• Processor number 1 processor included
• Processor speed 2.40 GHz
• Storage controller HPE MR408i-o Gen11 x8 Lanes 4GB Cache OCP SPDM Storage Controller
• Optical drive type Optional. None ship standard.
• Network controller Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE
• Warranty 3/3/3: Server Warranty includes three years of parts, three years of labor, and three years of on-site support coverage. Additional information regarding worldwide limited warranty and technical support is available at: https://support.hpe.com/hpesc/public/docDisplay?docId=sd00004309en_us. Additional HPE support and service coverage for your product can be purchased locally. For information on availability of service upgrades and the cost for these service upgrades, refer to the HPE website at https://www.hpe.com/support.
• Security UEFI Secure Boot and Secure Start support. Intel® Software Guard Extensions (SGX) support. Immutable Silicon Root of Trust. TPM (Trusted Platform Module) 2.0 support. Front bezel key-lock feature, Intrusion Cable (Included), Padlock slot and Kensington Lock slot support.
• Power supply type 2x HPE 1000W Flex Slot Titanium Hot Plug Power Supply Kit
• Infrastructure management HPE iLO Standard with Intelligent Provisioning (embedded), HPE OneView Standard (requires download); HPE iLO Advanced, HPE OneView Advanced (require licenses), and HPE Compute Ops Management.
• Expansion slots Default with 4 x8 PCIe 5.0 slots. Refer to the QuickSpecs for more detail.
• Memory type HPE DDR5 Smart Memory
• Processor cache 30 MB L3
• Processor core available 12 core
• System fan features 3x Standard Fans

Quickspecs

• QuickSpecs
• QuickSpecs (PDF)
• QuickSpecs (HTML)
• QuickSpecs

Overview

Are you looking for a robust and flexible tower optimized server for your SMB and remote offices? The HPE ProLiant ML350 Gen11 is a powerful 2P tower server with optional rackable chassis for various environments, and delivers exceptional compute performance, security, reliability, and expandability. Powered by 4th and 5th Gen Intel® Xeon® Scalable Processors up to 64 cores[1], up to 8 TB DDR5, PCIe Gen5, enhanced I/O and GPU support, and EDSFF storage, the HPE ProLiant ML350 Gen11 server fulfills a wide range of demanding workloads. The silicon root of trust anchors the server firmware to an HPE-exclusive ASIC, creating a fingerprint for the 4th and 5th Gen Intel Xeon Scalable processors that must be matched exactly before the server will boot. The HPE ProLiant ML350 Gen11 server is an excellent choice for diverse workloads such as IT infrastructure, Data Management, VDI, ERP/CRM. Scale and adapt to any environment with this server and accelerate your growing business.

What’s new

• Supports hot-pluggable, high-availability, RAID1 protected M.2 NVMe boot option.
• Support NVIDIA RTX 4000 Ada Graphics Accelerator, L40 48 GB Accelerator, A16 64 GB Accelerator and L4 24 GB Accelerator.
• Powered by 4th and 5th Gen Intel® Xeon® Scalable Processors that support up to 64 cores[1] (128 cores per server), 350W TDP. Increased memory bandwidth to 5600 MT/s[2], up to 8TB DDR5 memory capacity.
• Supports new EDSFF E3.S NVMe form factor to enable higher-density servers and storage systems, optimization of PCIe lanes from CPUs, and ultra-high SSD performance.
• Advanced data transfer rates from the PCIe Gen5 serial expansion bus, support up to 10 standard PCIe Gen5 slots and 2 OCP 3.0 slots [3].
• Includes HPE Integrated Lights-Out 6 (iLO 6) server management software that enables you to securely configure, monitor, and update your HPE ProLiant Gen11 servers seamlessly from anywhere.

Features

Intuitive Cloud Operating Experience: Simple, Self-service, and Automated

HPE ProLiant ML350 Gen11 servers are engineered for your hybrid world. The new ProLiant Gen11 servers simplify the way you control your business’s compute—from edge to cloud—with a cloud operating experience.

Transform business operations and pivot your team from reactive to proactive with global visibility and insight through a self-service console.

Automate tasks for efficiency in deployment, instant scalability, and seamless, simplified support and lifecycle management reducing tasks and shortening maintenance windows.

These experiences are engineered and built into all HPE ProLiant Gen11 servers, whether purchased as physical servers or consumed as-a-service using GreenLake Flex Solutions as your compute and storage demands grow.

Simplify and secure server management from edge to cloud with HPE Compute Ops Management. HPE Compute Ops Management is an as-a-service compute management experience that delivers greater simplicity, agility, and speed across your entire compute landscape, globally.

Trusted Security by Design: Uncompromising, Fundamental, and Protected

HPE ProLiant ML350 Gen11 server uses the silicon root of trust to anchor the firmware of an HPE ASIC, creating an immutable fingerprint for the Intel Processor that must be matched exactly before the server will boot. This verifies that malicious code is contained, and healthy servers are protected.

Optimized Performance for your Workloads: Accelerated, Open, and Efficient

The HPE ProLiant ML350 Gen11 server is an excellent choice for Compute and data storage demanding workloads (AI, ML, telco, DB analytics,) requiring high core count, GPU capabilities, and network and I/O bandwidth.

Harness major compute performance. The HPE ProLiant ML350 Gen11 server is powered by 4th and 5th Gen Intel® Xeon® Scalable Processors that support up to 64 cores[1] (128 cores per server) at 350W TDP.

Enjoy advanced data transfer rates and higher network speeds from the PCIe Gen5 serial expansion bus, with up to 4 x16 PCIe Gen5 and 2 x16 OCP slots to improve I/O throughput and reduce latency.

Utilize 32 DIMM channels for up to 8 TB DDR5 memory with increased memory bandwidth and performance, and lower power requirements.

Industry-leading Services and Ease of Deployment

The HPE ProLiant ML350 Gen11 server comes with a complete set of HPE Services, delivering confidence, reducing risk, and helping customers realize agility and stability.

HPE Services simplify all stages of the IT journey. Advisory and Transformation Services professionals understand customer challenges and design an effective solution. Professional Services enable rapid deployment of solutions and Operational Services provide ongoing support.

Services provided under Operational Services include: HPE Flexible Capacity, HPE Datacenter Care, HPE Infrastructure Automation, HPE Campus Care, HPE Proactive Services and multi-vendor coverage.

HPE IT investment solutions help you transform to a digital business with IT economics that align to your business goals.

Benefit from real-time operational feedback on server performance plus recommendations for fine-tuning BIOS settings to customize for changing business needs.

HPE ProLiant Gen11 servers continuously protect healthy servers at the edge by providing rapid detection of security-compromised servers, even to the point of not allowing them to boot if it identifies and contains malicious code, with IDevID certificates installed by default.

HPE ProLiant Gen11 servers provide automated recovery from a security event, including restoration of validated firmware, and facilitating recovery of the operating system, application, data connections, and providing a fast path to bring a server back online and into normal operations.

From silicon to software, from factory to cloud, and from generation to generation, HPE ProLiant Gen11 is engineered with a fundamental security approach to defend against increasingly complex threats through an uncompromising commitment to constant security advancements that are built into our DNA.

Media

HPE ProLiant Gen11 – Intel family – brief animated tour video for social media

New HPE ProLiant Gen11 servers are engineered for the hybrid world to deliver an intuitive cloud operating experience, trusted security by design, and optimized performance.

HPE ProLiant Gen11 servers with Intel Xeon – animated video

New HPE ProLiant Gen11 servers are engineered for the hybrid world to deliver an intuitive cloud operating experience, trusted security by design, and optimized performance – all while supporting a wide range of workloads that enable businesses to modernize and accelerate new innovations.

HPE ProLiant Gen11 servers with 4th Gen Intel® Xeon® Scalable Processors | Chalk Talk

In this Chalk Talk, learn about the new portfolio of HPE ProLiant Gen11 servers with 4th Gen Intel® Xeon® Scalable Processors.

HPE ML350 Gen11 3D virtual tour animated video

The new HPE ProLiant ML350 Gen11 server is ideal for remote/branch offices and engineering workloads with its next gen performance, expandability, and energy efficiency.

Compatible products

• Intel Xeon-Silver 4410Y 2.0GHz 12-core 150W Processor for HPE
• HPE 2.4TB SAS 12G Mission Critical 10K SFF BC 3-year Warranty 512e Multi Vendor HDD
• HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
• HPE 300GB SAS 12G Mission Critical 10K SFF BC 3-year Warranty Multi Vendor HDD
• HPE 1800W-2200W FS Ti Ht Plg PS Kit
• HPE 3.2TB NVME MU SFF BC U.3 PM1735A SSD
• HPE 500W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
• HPE 1.92T NVMERI SFF BC U.3ST V2 MV SSD
• HPE 3 Year Tech Care Essential ML350 Gen11 Smart Choice Service
• HPE 1TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty Multi Vendor HDD
• HPE 3.2TB SAS 24G Mixed Use SFF BC Multi Vendor SSD
• HPE 2TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty Multi Vendor HDD
• HPE LTO-8 Ultrium 30TB RW Data Cartridge
• HPE MR416I-P GEN11 SPDM STORAGE CNTLR
• HPE 5 Year Tech Care Essential ML350 Gen11 Smart Choice Service
• HPE 5 Year Tech Care Basic ML350 Gen11 Smart Choice Service
• HPE StoreEver LTO-7 Ultrium 15000 External Tape Drive
• Memorie RAM Server HPE Smart Memory Kit, 64GB DDR5, 4800Mhz, CL40
• Intel Xeon-Gold 5515+ 3.2GHz 8-core 165W Processor for HPE
• HPE 8TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty 512e Multi Vendor HDD
• HPE 16TB SAS 12G Business Critical 7.2K LFF LP 1-year Warranty Helium 512e ISE Multi Vendor HDD
• HPE StoreEver LTO-8 Ultrium 30750 Internal Tape Drive
• HPE StoreEver LTO-8 Ultrium 30750 External Tape Drive
• HPE T750 Gen5 INTL UPS with Management Card Slot
• Broadcom BCM57504 Ethernet 10/25Gb 4-port SFP28 Adapter for HPE
• HPE SN1610Q 32Gb 1-port Fibre Channel Host Bus Adapter
• HPE 7.68TB SATA RI SFF BC MV SSD
• HPE 8TB SAS 12G Business Critical 7.2K LFF LP 1-year Warranty 512e Multi Vendor HDD
• HPE 480GB SATA 6G Read Intensive SFF BC Multi Vendor SSD
• HPE Smart Storage Hybrid Capacitor with 145mm Cable Kit
• HPE ProLiant ML350 Gen11 Standard Heat Sink Kit
• HPE 480GB SATA 6G Mixed Use SFF BC Multi Vendor SSD
• HPE 7.68T NVMERI SFF BC U.3ST V2 MV SSD
• HPE C13 – C14 WW 250V 10Amp 2.0m Jumper Cord
• BCM 57414 10/25GbE 2p SFP28 Adptr
• INT XEON-G 6526Y CPU FOR HPE
• HP OV 3yr 24×7 Supp Flex E-LTU
• HPE ProLiant Compute ML350 Gen11/Gen12 Smart Storage Battery Cable Kit
• Intel Xeon-Silver 4510 2.4GHz 12-core 150W Processor for HPE
• HPE 1 Mini SAS HD – 4 Mini SAS FO 4
• HPE SN1610Q 32Gb 2-port Fibre Channel Host Bus Adapter
• HPE 3.84TB SATA 6G Read Intensive SFF BC Multi Vendor SSD
• HPE MR408i-o Gen11 x8 Lanes 4GB Cache OCP SPDM Storage Controller
• Intel Xeon-Gold 5416S 2.0GHz 16-core 150W Processor for HPE
• HPE T1000 Gen5 INTL UPS with Management Card Slot
• HPE 1.92TB SATA 6G Mixed Use SFF BC Multi Vendor SSD
• Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T Adapter for HPE
• HPE 96W Smart Storage Lithium-ion Battery with 145mm Cable Kit
• HPE 1.92TB SATA 6G Read Intensive SFF BC Multi Vendor SSD
• Memorie RAM Server HPE SmartMemory, 32GB DDR5, 5600Mhz, CL45
• HPE 3 Year Tech Care Basic ML350 Gen11 Smart Choice Service
• HPE 960GB SATA 6G Mixed Use SFF BC Multi Vendor SSD
• HPE ML350 GEN11 LFF OROC CBL KIT
• HPE 600GB SAS 10K SFF BC MV HDD
• HPE 1.92TB NVMe RI SFF BC U.3 CM7 SSD
• HPE iLO Advanced Electronic License with 3yr Support on iLO Licensed Features
• HPE 12TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty Helium 512e Multi Vendor HDD
• HPE 1.8TB SAS 10K SFF BC 512E MV HDD
• Intel I350-T4 Ethernet 1Gb 4-port BASE-T Adapter for HPE
• HPE 20TB SATA 7.2K LFF LP ISE MV HDD
• HPE 4TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty Multi Vendor HDD
• HPE ProLiant ML350 Gen11 4LFF SAS/SATA Basic Drive Cage Kit
• HPE Proliant DL/ML Startup Service
• HPE Proliant DL/ML Install Service
• HPE 9.5mm SATA DVD-RW Optical Drive
• HPE 1000W Flex Slot Titanium Hot Plug Power Supply Kit
• HPE Smart Array E208e-p SR Gen10 (8 External Lanes/No Cache) 12G SAS PCIe Plug-in Controller
• HPE 1600W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
• INT XEON-G 6426Y CPU FOR HPE
• INT XEON-G 6430 CPU FOR HPE
• Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE
• HPE 1.92TB NVMe Gen4 High Performance Read Intensive SFF BC U.3 PM1733a SSD
• MLX MCX631102 10/25GBE 2P SFP28 ADPTR
• INT Xeon-G 5418Y CPU for HPE
• HPE ML350 GEN11 SEC CPU FAN KIT
• HPE 800W Flex Slot Titanium Hot Plug Low Halogen Power Supply Kit
• HPE 4TB SAS 12G Business Critical 7.2K LFF LP 1-year Warranty Multi Vendor HDD
• HPE 960GB SATA 6G Read Intensive SFF BC Multi Vendor SSD
• HPE 96W Smart Storage Lithium-ion Battery with 260mm Cable Kit
• HPE 960GB SAS 12G Mixed Use SFF BC Value SAS Multi Vendor SSD
• HPE LTO-7 Ultrium 15000 Internal Tape Drive
• HPE LTO-7 Ultrium 15TB RW Data Cartridge
• HPE iLO Advanced 1-server License with 3yr Support on iLO Licensed Features
• HPE SN1610E 32GB 2P FC HBA
• HPE MR216i-p Gen11 x16 Lanes without Cache PCI SPDM Plug-in Storage Controller
• Memorie RAM Server HPE Smart Memory Kit, 16GB DDR5, 2800Mhz, CL45
• INT Xeon-G 6530 CPU for HPE
• HPE Mobile USB DVD-RW Optical Drive
• HPE 1.6TB NVMe Gen4 High Performance Mixed Use SFF BC U.3 PM1735a SSD
• HPE LTO-9 45TB RW DATA CARTRIDGE
• Memorie RAM Server HPE Smart Memory Kit, 64GB DDR5, 5600 Mhz, CL45
• Memorie RAM Server HPE Smart Memory Kit, 32GB DDR5, 4800Mhz, CL40
• HPE iLO Advanced 1-server License with 1yr Support on iLO Licensed Features
• Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T OCP3 Adapter for HPE
• Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T Adapter for HPE
• HPE 16TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty Helium 512e ISE Multi Vendor HDD
• HPE 16GB 1RX8 PC5-4800B-R SMART KIT
• BCM 57412 10GBE 2P SFP+ OCP3 ADPTR
• Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ Adapter for HPE
• INT XEON-S 4514Y CPU FOR HPE
• HPE LTO-6 Ultrium 6.25TB RW Data Cartridge
• HPE 1 Mini SAS HD – 4 Mini SAS FO 2M Cbl
• HPE 240GB SATA 6G Read Intensive SFF BC Multi Vendor SSD
• HPE 3.84TB SAS RI SFF BC VS MV SSD
• HPE MR416i-o Gen11 x16 Lanes 8GB Cache OCP SPDM Storage Controller
• HPE 960GB SATA 6G Read Intensive LFF LPC Multi Vendor SSD
• HPE iLO Advanced Electronic License with 1yr Support on iLO Licensed Features
• HPE Smart Storage Hybrid Capacitor with 260mm Cable Kit
• HPE MR216i-o Gen11 SPDM Storage Cntlr
• HPE T1000 G5 NA/JP Tower UPS
• HPE 7.68TB SAS 12G Read Intensive SFF BC Value SAS Multi Vendor SSD
• Intel I350-T4 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE
• HPE 12TB SAS 12G Business Critical 7.2K LFF LP 1-year Warranty Helium 512e Multi Vendor HDD
• HPE 1.2TB SAS 12G Mission Critical 10K SFF BC 3-year Warranty Multi Vendor HDD
• HPE NS204i-u Gen11 NVMe Hot Plug Boot Optimized Storage Device
• HPE 9.5mm SATA DVD-ROM Jb Gen9 Kit

Documents

• HPE ProLiant ML350 Gen11 QuickSpecs
• HPE ProLiant ML350 Gen11 #UKDoC TPS-I023

[1] Support up to 64-core with 5th Gen Intel processor and 60-core with 4th Gen Intel processor

[2] DDR5 5600 MT/s memory is limited to support with 5th Gen Intel processors. The maximum memory speed is a function of the memory type, memory configuration, and processor model.

[3] OCP and two tertiary riser PCIe slots are shared with 3 internal MICO connectors.